Chemotherapy, Radiotherapy and Bevacizumab in Patients With Unresectable Stage III Non-Small-Cell Lung Cancer

Inclusion Criteria: * Clinically confirmed non-small cell lung cancer stage IIIA and selected stage IIIB * Measurable or evaluable disease * Be up and about and able to care for self * Adequate kidney, liver and bone marrow function * No prior treatment for this disease * Must be able to give written informed consent * Must be able to take folic acid, vitamin B12 and dexamethasone as described in the protocol * Age 18 years or older Exclusion Criteria: * Stage IV or IIIB patients with pleural or pericardial effusions * Stage IIIB disease with contralateral mediastinal nodes greater than 4cm * Squamous cell predominant tumors * Pregnant or lactating women * Patients with active infections * History of another cancer within the last 5 years with the exception of skin cancer or cervical carcinoma in situ * History of stroke, transient ischemic attacks, or acute MI within the past 6 months or any other serious cardiovascular disease * Symptoms of peripheral vascular disease * History of neurological disease * Recent history of blood in the sputum or vomitus * Non-healing wounds, ulcer or long bone fractures * History of bleeding problems or coagulation problems * History of abdominal fistula, gastrointestinal perforation or intraabdominal abscess within 6 months * History of uncontrolled hypertension * Chronic use of non-steroidal anti-inflammatory medication not allowed on this study Please note: There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons. If you do qualify, study personnel will explain the trial in detail and answer any questions you may have. You can then decide if you wish to participate.