Pleurectomy/Decortication With Intraoperative Intrathoracic/Intraperitoneal Heated Cisplatin With Sodium Thiosulfate

Inclusion Criteria: * Histopathologic confirmation of malignant pleural mesothelioma * Patients who are able to tolerate surgical cytoreduction but unable to undergo extrapleural pneumonectomy due to poor cardiopulmonary reserve or tumor invasion or those with minimal disease * Male on non-pregnant female * 18 years of age or older * No evidence of spread outside the ipsilateral hemithorax by chest CT and chest MRI * Ejection fraction \> 45% * Pre-operative WBC \> 4K/uL * Estimated life expectancy of at least 12 weeks * Evidence of adequate renal and hepatic function * Grossly normal contralateral pulmonary function with a chest radiograph and chest CT scan * Karnofsky performance status of 70% or greater * No evidence of disease progression by chest CT or chest MRI, obtained at 8 weeks following surgery Exclusion Criteria: * Extended disease outside the ipsilateral hemithorax as determined on pre-operative radiographs or intraoperative findings * Positive extrapleural nodes as determined by mediastinoscopy * Gross disease (estimated thickness \> 10mm at any intrathoracic location) present within the hemithorax after surgery * Evidence of distant metastatic disease * Severe non-malignant co-morbid disease, uncontrolled angina, myocardial infarction on the past 6 months, renal insufficiency, liver disease, pulmonary hypertension * Pregnant or breast-feeding * Serious concomitant systemic disorders * Presence of active concomitant malignancy * Psychiatric or addictive disorders, which would preclude informed consent * Previous chemotherapy or radiation therapy for mesothelioma * Chemotherapy or radiation therapy administered within 3 years for another malignancy