Natrecor in Pulmonary Hypertension
The goal of this clinical research study is to learn if the drug nesiritide (Natrecor) is effective in lowering the pressure in your lungs. The primary objective of this study is to establish that Nesiritide (Natrecor) is effective in reducing pulmonary hypertension (PHTN) acutely as measured by a 20% reduction in the mean pulmonary arterial (PA) pressure. The secondary objectives will include: improvement in pulmonary vascular resistance (PVR), patient symptoms, exercise tolerance, frequency of toxicity, and surgeon's willingness to proceed with operation.
Ask AI to explain this studyKey things to know
This describes the study’s primary purpose.
The study team can explain what participation involves.
These are broad labels—not an eligibility decision.
Checked against the public recordLast updated Nov 7, 2018 · Source: ClinicalTrials.gov
Ask the study team to confirm whether enrollment is open.
Interventional
Locations may change over time.
Study sponsor
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 4
- Sponsor
- M.D. Anderson Cancer Center
- Interventions being studied
- Drug: Nesiritide (Natrecor); Procedure: Right Heart Catheterization
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
The sponsor separates these requirements into two groups. You do not need to interpret them alone—use them to guide a conversation with the study team.
1. Ages 18 to 85 years old. 2. Evidence of underlying lung disease by history and physical and/or chest x-ray and/or pulmonary function testing (PFT's). 3. PHTN documented by Doppler Echocardiography ( Done with in last 30 days) 4. Must be able to give an informed consent.
1. Patients with clinically significant hypotension (defined as a systolic blood pressure (SBP) \<90). 2. Active infection or sepsis as defined by fever and need for IV antibiotics. 3. Creatinine greater than 3.0 mg/dl 4. Significant valvular disease as a cause for the PHTN. 5. Severe Thrombocytopenia (as defined by platelets less than 20,000 or INR \> 1.6. 6. Left Ventricle Ejection Fraction (LVEF) \<40% (must be done with in the last 30 days prior to signing consent). 7. Hypersensitivity to nesiritide or any of it's components.
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- MD Anderson Cancer CenterHouston, Texas
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Nov 7, 2018. Always confirm current availability with the study team.