Combination Chemotherapy and Exisulind in Treating Patients With Extensive-Stage Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Exisulind may make tumor cells more sensitive to chemotherapy. Combining chemotherapy with exisulind may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining chemotherapy with exisulind in treating patients who have extensive-stage small cell lung cancer.
Checked against the public recordLast updated Dec 7, 2016 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Alliance for Clinical Trials in Oncology
- Interventions being studied
- Drug: carboplatin; Drug: etoposide; Drug: exisulind
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed small cell lung cancer * At least 1 unidimensionally measurable lesion * At least 20 mm by conventional techniques OR * At least 10 mm by spiral CT scan * Lesions considered nonmeasurable include: * Bone lesions * Leptomeningeal disease * Ascites * Pleural/pericardial effusion * Abdominal masses that are not confirmed and followed by imaging techniques * Cystic lesions * Tumor lesions situated in a previously irradiated area * Must not be considered for combined chemotherapy and radiotherapy * No active CNS metastases PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * ECOG 0-2 Life expectancy: * Not specified Hematopoietic: * Granulocyte count at least 1,500/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic: * Bilirubin normal * AST no greater than 2 times ULN * No clinically significant hepatic disease Renal: * Creatinine no greater than 2.0 mg/dL OR * Creatinine clearance at least 60 mL/min * No clinically significant renal disease Cardiovascular: * No clinically significant cardiac disease Other: * Not pregnant or nursing * Fertile patients must use effective contraception * No concurrent uncontrolled illness * No known sensitivity to sulindac PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * See Disease Characteristics * No prior chemotherapy for small cell lung cancer * No other concurrent chemotherapy Endocrine therapy: * No concurrent hormonal agents except: * Steroids for adrenal failure * Hormones for nondisease-related conditions (e.g., insulin for diabetes) * Intermittent use of dexamethasone as an antiemetic Radiotherapy: * See Disease Characteristics * At least 2 weeks since prior radiotherapy, including for palliation * No concurrent radiotherapy Surgery: * Not specified Other: * More than 7 days since prior sulindac * No concurrent sulindac
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- Northeast Alabama Regional Medical CenterAnniston, Alabama
- Rebecca and John Moores UCSD Cancer CenterLa Jolla, California
- Cedars-Sinai Medical CenterLos Angeles, California
- Veterans Affairs Medical Center - San DiegoSan Diego, California
- UCSF Comprehensive Cancer CenterSan Francisco, California
- Veterans Affairs Medical Center - San FranciscoSan Francisco, California
- CCOP - Christiana Care Health ServicesNewark, Delaware
- Lombardi Cancer CenterWashington D.C., District of Columbia
- Walter Reed Army Medical CenterWashington D.C., District of Columbia
- Veterans Affairs Medical Center - Washington, DCWashington D.C., District of Columbia
- Broward General Medical CenterFort Lauderdale, Florida
- Memorial Regional Hospital Comprehensive Cancer CenterHollywood, Florida
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Dec 7, 2016. Always confirm current availability with the study team.