Topotecan and Paclitaxel in Treating Patients With Recurrent or Refractory Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of topotecan and paclitaxel in treating patients who have recurrent or refractory small cell lung cancer.
Checked against the public recordLast updated Jul 13, 2016 · Source: ClinicalTrials.gov
What this study is about
- Purpose
- Treatment
- Study type
- Interventional
- Phase
- Phase 2
- Sponsor
- Alliance for Clinical Trials in Oncology
- Interventions being studied
- Drug: paclitaxel; Drug: topotecan hydrochloride; Radiation: radiation therapy
How this study is categorized
These labels come from structured fields and exact terms in the public record.
Who may be able to participate
DISEASE CHARACTERISTICS: * Stratum A (less than 3 months since prior therapy) closed to accrual effective 06/20/2000) * Histologically or cytologically confirmed recurrent or refractory small cell lung cancer * Only 1 prior regimen allowed (an alternating regimen with cyclophosphamide/doxorubicin/vincristine and etoposide/cisplatin is acceptable) * No mixed histology * Measurable or evaluable disease that has not been in the field of prior radiotherapy * No uncontrolled CNS metastases (treated CNS metastases eligible) PATIENT CHARACTERISTICS: Age: * 18 and over Performance status: * ECOG 0-2 Hematopoietic: * Absolute neutrophil count at least 2,000/mm\^3 * Platelet count at least 100,000/mm\^3 Hepatic: * Total bilirubin no greater than 1.5 times upper limit of normal (ULN) OR * Direct bilirubin normal Renal: * Creatinine no greater than 1.5 times ULN Cardiovascular: * No unstable angina pectoris * No uncontrolled congestive heart failure * No myocardial infarction within the past 3 months Other: * No uncontrolled infections * No other concurrent malignancy except skin cancer or localized prostate cancer * Not pregnant or nursing * Negative pregnancy test * Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: * Not specified Chemotherapy: * See Disease Characteristics * No prior topoisomerase I inhibitor (e.g., topotecan or irinotecan) or taxane (e.g., paclitaxel or docetaxel) * At least 3 months since other prior chemotherapy Radiotherapy: * See Disease Characteristics * At least 2 weeks since prior radiotherapy * No concurrent radiotherapy Surgery: * At least 3 weeks since any prior major surgery
Important: This is the sponsor’s public criteria, not a determination of eligibility. The study team must review your individual situation.
U.S. locations
- CCOP - Scottsdale Oncology ProgramScottsdale, Arizona
- CCOP - Illinois Oncology Research AssociationPeoria, Illinois
- CCOP - Carle Cancer CenterUrbana, Illinois
- CCOP - Cedar Rapids Oncology ProjectCedar Rapids, Iowa
- CCOP - Iowa Oncology Research AssociationDes Moines, Iowa
- Siouxland Hematology-OncologySioux City, Iowa
- CCOP - WichitaWichita, Kansas
- CCOP - OchsnerNew Orleans, Louisiana
- CCOP - DuluthDuluth, Minnesota
- Mayo Clinic Cancer CenterRochester, Minnesota
- CentraCare Health PlazaSaint Cloud, Minnesota
- CCOP - Missouri Valley Cancer ConsortiumOmaha, Nebraska
Source and freshness
Processed from ClinicalTrials.gov. Last public update: Jul 13, 2016. Always confirm current availability with the study team.